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Price Target on Cancer Drug Co. Boosted

Source: Joseph Pantginis

 

August 23, 2022 (Investorideas.com Newswire) The price target was increased by 66% to reflect the full potential opportunity of the biopharma's drug candidate for hepatocellular carcinoma, a key driver going forward, noted an H.C. Wainwright & Co. report.


H.C. Wainwright & Co. raised its price target on Medivir AB (MVIR-B:STO) to SEK50 from SEK30 to wholly reflect the potential opportunity with its clinical stage drug fostrox in hepatocellular carcinoma, Joseph Pantginis, an analyst with the financial firm, reported in an August 19, 2022 research note. This new target, assigned after Medivir's Q2/22 financial and corporate update, implies significant potential return for investors from the biopharma's current price of SEK7.84.

In a financial overview of Medivir's Q2/22, Pantginis noted the company posted an earnings per share (EPS) of -SEK0.42. In comparison, consensus and H.C. Wainwright's EPS estimates were -SEK0.41 and -SEK0.58, respectively. At quarter's end, Medivir had SEK162.8 million in cash.

Operationally during Q2/22, Medivir continued advancing fostrox, or fostroxacitabine bralpamide, which is in the early stages of a Phase 1b/2a clinical trial in patients with hepatocellular carcinoma, a difficult to treat group, Pantginis relayed. Fostrox will remain a primary focus and key driver for this Swedish cancer drug developer.

Fostrox "has the potential to become the first liver-targeted and orally administered drug for patients with hepatocellular carcinoma and other forms of liver cancer," Pantginis commented. "It has a strong potential as a combination agent with cyclin-dependent inhibitors or tyrosine kinase inhibitors."

In Phase 1b of the current trial, two parallel dose streams of fostrox are being assessed to establish the recommended dose for Phase 2a. The second phase, an expansion study, will evaluate the safety and efficacy of fostrox in combination with lenvatinib and/or fostrox in combination with Keytruda.

Enrollment has been going more slowly than expected. However, dosing of enrolled patients is underway, and the plan to submit an investigational new drug application, including initial safety and efficacy data, to the U.S. Food and Drug Administration in 2023 remains on schedule. Pantginis attributed lagging enrollment to a number of studies competing for the same population now that COVID-19 restrictions are mostly behind us.

To help speed up enrollment, Medivir is employing new strategies. It amended the patient criteria, making it easier for them to qualify. Also, the company is adding investigators and trial sites and increasing its presence at the active centers. There are now 15 active sites in Spain, the United Kingdom, and South Korea.

"Hepatocellular carcinoma is particularly common in Asia, and the trial could provide the opportunity for increased interaction with sites and key opinion leaders as well as key exposure to potential partners in this territory," wrote Pantginis.

In other Medivir news, "the company's out-licensed candidates are progressing as planned," Pantginis pointed out. For instance, the first dose escalation cohort was cleared in the Phase 1 trial of Medivir's birinapant in combination with IGM Biosciences' DR5-agonist antibody IGM-8444 in solid tumors. Initial data are expected soon.

H.C. Wainwright & Co. has a Buy rating on Medivir.

Disclosures:

1) Doresa Banning wrote this article for Streetwise Reports LLC and provides services to Streetwise Reports as an independent contractor. She or members of her household own securities of the following companies mentioned in the article: None. She or members of her household are paid by the following companies mentioned in this article: None.

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Disclosures For H.C. Wainwright & Co., Medivir AB, Aug. 19, 2022

H.C. Wainwright & Co, LLC (the "Firm") is a member of FINRA and SIPC and a registered U.S. Broker-Dealer.

I, Joseph Pantginis, Ph.D. , certify that 1) all of the views expressed in this report accurately reflect my personal views about any and all subject securities or issuers discussed; and 2) no part of my compensation was, is, or will be directly or indirectly related to the specific recommendation or views expressed in this research report; and 3) neither myself nor any members of my household is an officer, director or advisory board member of these companies.

None of the research analysts or the research analyst's household has a financial interest in the securities of Medivir AB and IGM Biosciences, Inc. (including, without limitation, any option, right, warrant, future, long or short position). As of July 31, 2022 neither the Firm nor its affiliates beneficially own 1% or more of any class of common equity securities of Medivir AB and IGM Biosciences, Inc.. Neither the research analyst nor the Firm knows or has reason to know of any other material conflict of interest at the time of publication of this research report.

The research analyst principally responsible for preparation of the report does not receive compensation that is based upon any specific investment banking services or transaction but is compensated based on factors including total revenue and profitability of the Firm, a substantial portion of which is derived from investment banking services. The Firm or its affiliates did not receive compensation from Medivir AB and IGM Biosciences, Inc. for investment banking services within twelve months before, but will seek compensation from the companies mentioned in this report for investment banking services within three months following publication of the research report.

The Firm does not make a market in Medivir AB and IGM Biosciences, Inc. as of the date of this research report.

The securities of the company discussed in this report may be unsuitable for investors depending on their specific investment objectives and financial position. Past performance is no guarantee of future results. This report is offered for informational purposes only, and does not constitute an offer or solicitation to buy or sell any securities discussed herein in any jurisdiction where such would be prohibited. This research report is not intended to provide tax advice or to be used to provide tax advice to any person. Electronic versions of H.C. Wainwright & Co., LLC research reports are made available to all clients simultaneously.

H.C. Wainwright & Co., LLC does not provide individually tailored investment advice in research reports. This research report is not intended to provide personal investment advice and it does not take into account the specific investment objectives, financial situation and the particular needs of any specific person. Investors should seek financial advice regarding the appropriateness of investing in financial instruments and implementing investment strategies discussed or recommended in this research report.

H.C. Wainwright & Co., LLC's and its affiliates' salespeople, traders, and other professionals may provide oral or written market commentary or trading strategies that reflect opinions that are contrary to the opinions expressed in this research report. H.C. Wainwright & Co., LLC and its affiliates, officers, directors, and employees, excluding its analysts, will from time to time have long or short positions in, act as principal in, and buy or sell, the securities or derivatives (including options and warrants) thereof of covered companies referred to in this research report.

The information contained herein is based on sources which we believe to be reliable but is not guaranteed by us as being accurate and does not purport to be a complete statement or summary of the available data on the company, industry or security discussed in the report. All opinions and estimates included in this report constitute the analyst's judgment as of the date of this report and are subject to change without notice.

Securities and other financial instruments discussed in this research report: may lose value; are not insured by the Federal Deposit Insurance Corporation; and are subject to investment risks, including possible loss of the principal amount invested.

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