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Biopharma Expands Clinical Program of Lead Drug Candidate to Treat Chronic Cough

Source: Streetwise Reports

September 30, 2021 (Investorideas.com Newswire) Algernon Pharmaceuticals will now pursue Ifenprodil in chronic cough based on encouraging recent study results in a Phase 2 trial.


The market for cough remedies globally generated $7.08 billion in 2020, and that figure is expected to reach $9.91 billion by 2030, according to Allied Global Research.

In related news, Algernon Pharmaceuticals Inc. (AGN:CSE; AGNPF:OTCQB; AGW:FSE) decided to expand its clinical program aimed at repurposing NP-120 (Ifenprodil), with a Phase 2 trial focused solely on chronic cough.

The British Columbia-based biopharma investigates safe drugs or naturally occurring compounds, already approved but outside of the U.S. and Europe, for new disease applications then moves them through the clinic and approval process. Along with Ifenprodil, the biopharma is pursuing a clinical program of the psychedelic compound AP-188 (N,N-Dimethyltryptamine, or DMT) in stroke, another sizable market.

As the next step with lead drug candidate Ifenprodil, Algernon will file a pre-investigational new drug meeting request with the U.S. Food and Drug Administration for its input regarding a phase 2 trial of Ifenprodil, an NMDA receptor antagonist, solely in chronic cough, as noted in a news release.

A cough that lasts eight or more weeks in adults or four weeks in children is considered chronic.

The biopharma opted to pursue a standalone chronic cough study based on interim results of the chronic cough component of its 20-patient Phase 2 idiopathic pulmonary fibrosis (IPF) trial underway in Australia and New Zealand.

Chronic cough was included in this study because it is a symptom that occurs in a subset of patients with IPF. Oftentimes in this population, the cough is severe and more difficult to treat than in patients whose cough is due to other causes.

The encouraging study results consisted of 24-hour and waking cough counts measured with an ambulatory cough monitor at baseline and after four and 12 weeks of treatment: 20 milligrams of Ifenprodil three times a day.

The data showed that patients' cough counts at these two post-treatment times were lower than at baseline.

Unlike the combination IPF/chronic cough Phase 2 trial, the chronic cough-only study will be powered to ensure statistical significance and will include a placebo control.

Disclosures:

1) Doresa Banning compiled this article for Streetwise Reports LLC and provides services to Streetwise Reports as an independent contractor. She or members of her household own securities of the following companies mentioned in the article: None. She or members of her household are paid by the following companies mentioned in this article: None.

2) The following companies mentioned in this article are billboard sponsors of Streetwise Reports: Algernon Pharmaceuticals Inc. Click here for important disclosures about sponsor fees.

3) Comments and opinions expressed are those of the specific experts and not of Streetwise Reports or its officers. The information provided above is for informational purposes only and is not a recommendation to buy or sell any security.

4) The article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.

5) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the decision to publish an article until three business days after the publication of the article. The foregoing prohibition does not apply to articles that in substance only restate previously published company releases. As of the date of this article, officers and/or employees of Streetwise Reports LLC (including members of their household) own securities of Algernon Pharmaceuticals Inc., a company mentioned in this article.

6) This article does not constitute medical advice. Officers, employees and contributors to Streetwise Reports are not licensed medical professionals. Readers should always contact their healthcare professionals for medical advice.

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