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Biotech's New Mesothelioma Trial Data Show Efficacy, Immunogenicity

Source: Streetwise Reports

 

June 25, 2020 (Investorideas.com Newswire) These results of a study evaluating Targovax's lead candidate are reviewed and commented on in an H.C. Wainwright & Co. report.


In a June 22 research note, H.C. Wainwright & Co. analyst Joseph Pantginis reported that Targovax ASA's (TRVX:OSE) ONCOS-102, in trial results, showed efficacy and immunogenicity in malignant pleural mesothelioma (MPM) patients at 12 months post treatment.

ONCOS-102, Targovax's lead candidate, is an oncolytic adenovirus containing an immune-stimulating transgene. It recently was assessed in the randomized Phase 1/2 trial in combination with standard of care chemotherapy in 31 patients with MPM. In the study, the 20 members of the experimental group received both treatments whereas the 11 in the control group were treated only with standard of care chemotherapy.

Pantginis reviewed the study findings at 12 months and commented, "Given the potent immunogenicity, the data provide a strong rationale for the use of ONCOS-102 to enhance patients' responses to checkpoint inhibitor regimens and ameliorate outcomes."

Specifically, the data show that ONCOS-102-treated patients experienced clinical benefits that those in the control group did not experience or experienced to a lesser extent. Those benefits included increased infiltration of cytotoxic T cells in the tumor, upregulation in the expression of genes associated with adaptive immunity and cytotoxicity, polarization of macrophages toward the M1 pro-inflammatory anti-tumor phenotype and increased PD-L1 expression.

The trial results, Pantginis wrote, confirmed the previously reported 8.9 months of median progression-free survival, which compares to 7.6 months among the control group and 5.7–7.3 months historically for standard of care.

The survival rate among the patients who received the treatment combination was encouraging, at 64%, versus 50% among the control group patients, Pantginis noted.

The study findings also confirmed ONCOS-102's mechanism of action, which is "enhancing immune responses and modulating the tumor microenvironment and its consequent correlation with positive outcomes," relayed Pantginis. This suggests that "ONCOS-102 in combination with chemotherapy achieves responses with an extent similar to those obtained with CKI."

As such, Norway-based Targovax next plans to conduct one or more triple combination studies, testing ONCOS-102 plus standard of care chemotherapy plus a checkpoint inhibitor, in firstline MPM patients.

Pantginis concluded that all of the positive mesothelioma data Targovax has accumulated to date "provide strong rationale for moving mesothelioma forward as first path to market."

H.C. Wainwright & Co. has a Buy rating and an NOK19 per share price target on Targovax, the stock of which is currently trading at about NOK7.32 per share.

Disclosure:

1) Doresa Banning compiled this article for Streetwise Reports LLC and provides services to Streetwise Reports as an independent contractor. She or members of her household own securities of the following companies mentioned in the article: None. She or members of her household are paid by the following companies mentioned in this article: None.

2) The following companies mentioned in this article are billboard sponsors of Streetwise Reports: None. Click here for important disclosures about sponsor fees.

3) Comments and opinions expressed are those of the specific experts and not of Streetwise Reports or its officers. The information provided above is for informational purposes only and is not a recommendation to buy or sell any security.

4) The article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.

5) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the interview or the decision to write an article until three business days after the publication of the interview or article. The foregoing prohibition does not apply to articles that in substance only restate previously published company releases.

6) This article does not constitute medical advice. Officers, employees and contributors to Streetwise Reports are not licensed medical professionals. Readers should always contact their healthcare professionals for medical advice.

Disclosures from H. C. Wainwright, Targovax ASA, Company Update, June 22, 2020

Investment Banking Services include, but are not limited to, acting as a manager/co-manager in the underwriting or placement of securities, acting as financial advisor, and/or providing corporate finance or capital markets-related services to a company or one of its affiliates or subsidiaries within the past 12 months.

I, Joseph Pantginis, Ph.D., certify that 1) all of the views expressed in this report accurately reflect my personal views about any and all subject securities or issuers discussed; and 2) no part of my compensation was, is, or will be directly or indirectly related to the specific recommendation or views expressed in this research report; and 3) neither myself nor any members of my household is an officer, director or advisory board member of these companies.

None of the research analysts or the research analyst's household has a financial interest in the securities of Targovax ASA (including, without limitation, any option, right, warrant, future, long or short position).

As of May 31, 2020 neither the Firm nor its affiliates beneficially own 1% or more of any class of common equity securities of Targovax ASA.

Neither the research analyst nor the Firm has any material conflict of interest in of which the research analyst knows or has reason to know at the time of publication of this research report.

The research analyst principally responsible for preparation of the report does not receive compensation that is based upon any specific investment banking services or transaction but is compensated based on factors including total revenue and profitability of the Firm, a substantial portion of which is derived from investment banking services.

The Firm or its affiliates did not receive compensation from Targovax ASA for investment banking services within twelve months before, but will seek compensation from the companies mentioned in this report for investment banking services within three months following publication of the research report.

The Firm does not make a market in Targovax ASA as of the date of this research report.

H.C. Wainwright & Co., LLC and its affiliates, officers, directors, and employees, excluding its analysts, will from time to time have long or short positions in, act as principal in, and buy or sell, the securities or derivatives (including options and warrants) thereof of covered companies referred to in this research report.


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