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Coronavirus / BioPharma Stock News Bites: Applied DNA (NASDAQ: $APDN) and Takis Biotech Announce the Production of Neutralizing Antibodies Against SARS-CoV-2 After DNA Vaccination in Animals

Beyond expectations, a single injection of DNA in mice induced antibodies that block the infection of cultured human cells by SARS-CoV-2


May 4, 2020 ( Newswire) Coronavirus / BioPharma (COVID-19) Stock News Bites - Applied DNA Sciences Inc. (NASDAQ: APDN) ("Applied DNA" or the "Company" or "we/our") today announced with its COVID-19 vaccine development partner Takis Biotech ("Takis") that the first injections of the DNA vaccine candidates against the Spike protein (product of the S gene) of the SARS-CoV-2 virus, cause of the COVID-19 disease, have produced neutralizing antibodies in test animals. The studies were completed at the renowned Lazzaro Spallanzani ("Spallanzani") National Institute for Infectious Diseases in Rome. These initial results were obtained using plasmids (the templates for LinearDNA™) to baseline results; Applied DNA's linear DNA dose-response trials begin this week.

The Joint Development Agreement between Takis and the Company calls for the manufacture of the DNA vaccine candidates for both preclinical and human trials via Applied DNA's proprietary and patented LinearDNA PCR (Polymerase Chain Reaction) platform. This method of production is enzymatic and yields highly purified DNA, we believe without the risks of plasmid production in bacteria. Highly scalable, production can take place in the Company's headquarters in Stony Brook or can be disseminated in conventional pharmaceutical plants available globally. The LinearDNA vaccine candidates will use the patient as a "temporary bioreactor" to enable the production of Spike antigens in the patient for a period of about two weeks, we believe long enough to produce the immune response necessary to block the infection and the spread of SARS-CoV-2.

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