Preclinical Data for Alzheimer's Therapy to Be Presented at AAIC
Source: Streetwise Reports
July 11, 2018 (Investorideas.com Newswire) A poster outlining data from this company's lead candidate, which targets toxic oligomers identified as a potential cause of Alzheimer's disease, will be presented at the Alzheimer's Association International Conference (AAIC).
In a July 10 press release, ProMIS Neurosciences Inc. (PMN:TSX; ARFXF:OTCQB) announced it would be presenting preclinical data regarding PMN310 at the AAIC, to be held in Chicago beginning on July 22.
The company, which is focused on "discovery and development of antibody therapeutics targeting toxic oligomers implicated in the development of neurodegenerative diseases," will present a poster titled "Humanized PMN310 shows enhanced therapeutic potential by binding toxic low molecular weight Aβ oligomers while avoiding ARIA-related binding to Aβ deposits in AD patient brains."
In the announcement, ProMIS chief development officer Johanne Kaplan stated that PMN310 "may provide greater therapeutic potency and safety compared to other Aβ-directed antibodies due to its selective targeting of soluble toxic oligomers and the consequently reduced risk of amyloid related imaging abnormalities, or ARIA, allowing for safe administration of higher doses of antibody."
According to the company, the processes leading to development of Alzheimer's disease may not stem from plaques, but rather from toxic amyloid beta (Aβ) oligomers. PMN310, according to ProMIS president and CEO Dr. Elliot Goldstein, "selectively target[s] and neutralize[s] toxic Aβ oligomers with no significant off-target binding to Aβ monomers or plaque."
In the release, Dr. Goldstein expressed the company's belief that "the particular, oligomer selective profile of PMN310 supports a potential best in class profile compared to [other] Aβ therapeutic antibodies currently showing promising results in clinical trials."
The company plans to begin clinical trials for PMN310 in the second half of 2019.
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