Join our smart investors - Get the best stock directories in  blockchain, cannabis, crypto, AI, IoT, cleantech. Daily podcasts in cannabis and crpto. Just $99  a year

Coverage Initiated on Developer of Potential Breast Cancer Therapy Competitor

Source: Streetwise Reports


January 31, 2018 ( Newswire) Jason Kolbert, an analyst with Maxim Group, explained the drivers behind adding this drug and drug delivery developer to his coverage universe.

In a Jan. 26 research note, analyst Jason Kolbert reported that Maxim Group initiated coverage on Atossa Genetics Inc. (ATOS:NASDAQ) with a Buy rating and $2 per share target price (the stock is currently trading at around $0.74 per share). "We see multiple catalysts ahead as trials begin and data emerge in 2018," he added.

Atossa is developing the drug endoxifen that "could be better" than Tamoxifen, "the most widely used drug to prevent breast cancer recurrence," Kolbert noted. Endoxifen is one of the compounds into which Tamoxifen metabolizes.

The biotech is formulating endoxifen in two ways, both of which should enter Phase 2 clinical studies this year, Kolbert explained.

One is an oral form to prevent breast cancer recurrence in Tamoxifen-refractory patients. In Phase 1, oral endoxifen showed a positive safety profile and "endoxifen levels above the 30nM therapeutic threshold," Kolbert indicated.

The second formulation is a lotion for reducing high density breast tissue, or mammographic breast density, which increases the risk of someone developing cancer or can hide existing tumors. Kolbert noted that "the latter is critical as during the early stages of breast cancer, this could prevent women from receiving available viable therapies with high cure rates."

About both the oral and topical versions of endoxifen, Kolbert explained they are "505(b)2, based on known data for safety and efficacy of tamoxifen and its metabolite endoxifen, meaning potentially accelerated timelines to approvals."

With respect to Tamoxifen, the analyst noted it has "considerable side effects which create a real risk/reward scenario given the chronic nature of the therapy." Further, "up to 50% of women" poorly metabolize the drug and, therefore, receive an inadequate endoxifen dose. This can increases the chance of recurrence.

Atossa also a working on a "microcatheter delivery system for the intraductal delivery of drugs or biologics (including chimeric antigen receptor T cells [CAR-T]) directly into the breast," Kolbert wrote. This method of getting drugs to a patient via the nipple prevents the adverse side effects associated with systemic delivery.

A related study involving the breast cancer therapeutic fulvestrant is underway in Phase 2, where intraductal delivery via microcatheter is being evaluated against intramuscular injection in patients with estrogen receptor-positive ductal carcinoma in situ and Phase 1/2 (local) invasive breast cancer. "The study will evaluate safety, drug distribution, hormone receptor expression and effect on lesion size," said Kolbert.

Also in progress is preclinical evaluation of the microcatheter system in delivering CAR-T treatment to breast cancer patients. Kolbert noted, "The rationale is to minimize side effects like cytokine release syndrome and maximize CAR-T targeting to the tumor."

As for the potential value of Atossa's stock, Kolbert concluded that the company's therapeutic "candidates are known drugs with published safety and efficacy profiles, which is derisking." While Tamoxifen and fulvestrant cumulatively "generate about $2 billion" per year, "just a small portion of the market points to upside at the current ~10 million valuation," he said. Additional upside could come from the CAR-T program, "as it could attract a partner."


1) Doresa Banning compiled this article for Streetwise Reports LLC and provides services to Streetwise reports as an independent contractor. She or members of her household own securities of the following companies mentioned in the article: None. She or members of her household are paid by the following companies mentioned in this article: None.

2) The following company mentioned in this article is a billboard sponsor of Streetwise Reports: None. Streetwise Reports does not accept stock in exchange for its services. Click here for important disclosures about sponsor fees.

3) Comments and opinions expressed are those of the specific experts and not of Streetwise Reports or its officers. The information provided above is for informational purposes only and is not a recommendation to buy or sell any security.

4) The article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.

5) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the interview or the decision to write an article, until one week after the publication of the interview or article.

Additional Disclosures

Disclosures from Maxim Group, Atossa Genetics Inc., Jan. 26, 2018

I, Jason Kolbert, attest that the views expressed in this research report accurately reflect my personal views about the subject security and issuer. Furthermore, no part of my compensation was, is, or will be directly or indirectly related to the specific recommendation or views expressed in this research report.

I, Jason McCarthy, Ph.D., attest that the views expressed in this research report accurately reflect my personal views about the subject security and issuer. Furthermore, no part of my compensation was, is, or will be directly or indirectly related to the specific recommendation or views expressed in this research report.

The research analyst(s) primarily responsible for the preparation of this research report have received compensation based upon various factors, including the firm's total revenues, a portion of which is generated by investment banking activities.

Maxim Group makes a market in Atossa Genetics Inc.

Maxim Group managed/co-managed/acted as placement agent for an offering of the securities for Atossa Genetics Inc. in the past 12 months.

Maxim Group received compensation for investment banking services from Atossa Genetics Inc. in the past 12 months.

Maxim Group expects to receive or intends to seek compensation for investment banking services from Atossa Genetics Inc. in the next 3 months. - A Leading Global Investor Website for Biotech Industry Stocks - investing ideas in biotechnology stocks, medical technology and life sciences

Like Biotech Stocks? View our Biotech Stocks Directory

Get News Alerts on Biotech Stocks

More Info: Newswire

This news is published on the Newswire - a global digital news source for investors and business leaders

Disclaimer/Disclosure: is a digital publisher of third party sourced news, articles and equity research as well as creates original content, including video, interviews and articles. Original content created by investorideas is protected by copyright laws other than syndication rights. Our site does not make recommendations for purchases or sale of stocks, services or products. Nothing on our sites should be construed as an offer or solicitation to buy or sell products or securities. All investment involves risk and possible loss of investment. This site is currently compensated for news publication and distribution, social media and marketing, content creation and more. Contact each company directly regarding content and press release questions. Disclosure is posted for each compensated news release, content published /created if required but otherwise the news was not compensated for and was published for the sole interest of our readers and followers. More disclaimer info: Learn more about publishing your news release on the newswire

Additional info regarding BC Residents and global Investors: Effective September 15 2008 - all BC investors should review all OTC and Pink sheet listed companies for adherence in new disclosure filings and filing appropriate documents with Sedar. Read for more info: Global investors must adhere to regulations of each country.

Please read privacy policy: