Investorideas.com
Search  Follow Investorideas on Twitter  Investorideas is on Facebook  Investorideas is on Google Plus  Investorideas is on Youtube  Investorideas is on Pinterest  Investorideas is on tumblr  Investorideas is on LinkedIn  Investorideas RSS 


Investorideas podcasts on iTunes, Google Play Music and iHeart.com    Investorideas.com potcasts - cannabis news and stocks to watch plus insight from thought leaders and experts    Investorideas.com crypto corner    Play by Play – the latest sports headlines and sports stock news

 

Join Investor Ideas Members to access the Renewable Energy stocks directory, water stocks, biotech stocks, defense stocks directories and the Insiders Corner

Study Shows Biopharma's Lead Drug Mediates T Cell Tumor Infiltration

Source: Streetwise Reports

 

July 11, 2018 (Investorideas.com Newswire) An Echelon Wealth Partners report discussed this firm's stock performance and how a recent clinical trial update impacted it.


In a July 9 research note, analyst Douglas Loe reported that Echelon Wealth Partners designated IMV Inc. (IMV:TSX; IMMVD:OTCQX) a Top Pick for the fourth consecutive quarter. Since the biotech first earned the status, in September 2017, its stock "is up cumulatively by 91.8% and, even more dramatically, by 188.5% since we initiated coverage on IMV back in September 2016," he wrote.

Loe indicated that IMV's share price appreciation of 7.6% in Q2/18 "is hardly disappointing" but "does fall below our original expectations" arrived at in anticipation of the Phase 2 update on the company's lead drug DPX-Survivac to be given at the annual American Society of Clinical Oncology meeting in June 2018. The market responded to the update "a bit more skeptically" than Echelon did, Loe added, leading investors to view DPX-Survivac cautiously and, in turn, causing the stock to fall short of expectations.

Loe highlighted that Echelon disagreed with the market's interpretation of the update, believing the trial update warranted a positive, rather than guarded, position on the drug's prospects. Particularly compelling was the new information that DPX-Survivac likely facilitates T cell tumor infiltration, which the update "signaled," and perhaps enhances this effect by simultaneously inhibiting the PD1/PD-L1 pathway. Further supporting Echelon's stance, Loe added, is the response rate in the ongoing study of ovarian patients, which "was relatively strong in our view for this patient population."

Loe reminded readers that the study update data revealed six of eight patients treated with combination DPX-Survivac and high dose epacadostat showed stable disease to Day 56. At Day 140, two of the patients demonstrated evidence of tumor response, "an encouraging though early sign of time-dependent, immunologically based, anticancer activity achievable with DPX-Survivac-based therapy," he added.

The analyst reiterated that Echelon remains encouraged by the findings that tumor progression in treated patients was infrequent and equivalent to the number of patients who experienced partial response or stable disease while on DPX-Survivac and low dose epacadostat. He concluded, "We maintain our view that cumulative tumor response data to the level achieved so far for DPX-Survivac-treated recurrent ovarian cancer patients is medically relevant and merits further study."

Regarding the interaction between DPX-Survivac and the PD1/PD-L1 pathway, clinical studies that aim to investigate this are underway, for which interim data could be available in Q3/18, noted Loe.

In general, Echelon is bullish on IMV's DepoVax platform because "other DPX-formulated antigens have generated encouraging updates in recent quarters from other co-development partners," including Zoetis and Leidos, Loe said.

Looking forward, a potential Q3/18 catalyst is elucidation on how DPX-Survivac performs in ovarian cancer and B cell lymphoma patients when administered in combination with Keytruda. Were tumor response data from those two trials positive, they would be "highly validating for how DPX-Survivac's T cell-mediated antitumor activity could be enhanced by supplementally impacting tumor immunology through PD1/PD-L1 inhibition," commented Loe.

Echelon maintained its Speculative Buy rating and CA$12.25 per share price target on IMV. The latter implies an 87.3% return as the stock is currently trading at around CA$6.39 per share.

Disclosure:

1) Doresa Banning compiled this article for Streetwise Reports LLC and provides services to Streetwise reports as an independent contractor. She or members of her household own securities of the following companies mentioned in the article: None. She or members of her household are paid by the following companies mentioned in this article: None.

2) The following company mentioned in this article is a billboard sponsor of Streetwise Reports: None. Click here for important disclosures about sponsor fees.

3) Comments and opinions expressed are those of the specific experts and not of Streetwise Reports or its officers. The information provided above is for informational purposes only and is not a recommendation to buy or sell any security.

4) The article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.

5) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the interview or the decision to write an article, until one week after the publication of the interview or article.

Disclosures from Echelon Wealth Partners, IMV Inc., July 9, 2018

Echelon Wealth Partners compensates its Research Analysts from a variety of sources. The Research Department is a cost centre and is funded by the business activities of Echelon Wealth Partners including, Institutional Equity Sales and Trading, Retail Sales and Corporate and Investment Banking.

I, Doug Loe, hereby certify that the views expressed in this report accurately reflect my personal views about the subject securities or issuers. I also certify that I have not, am not, and will not receive, directly or indirectly, compensation in exchange for expressing the specific recommendations or views in this report.

Important Disclosures:

Is this an issuer related or industry related publication? Issuer.

Does the Analyst or any member of the Analyst’s household have a financial interest in the securities of the subject issuer? No

Does the Analyst or household member serve as a Director or Officer or Advisory Board Member of the issuer? No

Does Echelon Wealth Partners Inc. or the Analyst have any actual material conflicts of interest with the issuer? No

Does Echelon Wealth Partners Inc. and/or one or more entities affiliated with Echelon Wealth Partners Inc. beneficially own common shares (or any other class of common equity securities) of this issuer which constitutes more than 1% of the presently issued and outstanding shares of the issuer? No

During the last 12 months, has Echelon Wealth Partners Inc. provided financial advice to and/or, either on its own or as a syndicate member, participated in a public offering, or private placement of securities of this issuer? Yes

During the last 12 months, has Echelon Wealth Partners Inc. received compensation for having provided investment banking or related services to this Issuer? Yes

Has the Analyst had an onsite visit with the Issuer within the last 12 months? No

Has the Analyst or any Partner, Director or Officer been compensated for travel expenses incurred as a result of an onsite visit with the Issuer within the last 12 months? No

Has the Analyst received any compensation from the subject company in the past 12 months? No

Is Echelon Wealth Partners Inc. a market maker in the issuer’s securities at the date of this report? No


BiotechIndustryStocks.com - A Leading Global Investor Website for Biotech Industry Stocks

BiotechIndustryStocks.com - investing ideas in biotechnology stocks, medical technology and life sciences

Like Biotech Stocks? View our Biotech Stocks Directory

Get News Alerts on Biotech Stocks


More Info:

Investorideas.com Newswire

This news is published on the Investorideas.com Newswire - a global digital news source for investors and business leaders


Disclaimer/Disclosure: Investorideas.com is a digital publisher of third party sourced news, articles and equity research as well as creates original content, including video, interviews and articles. Original content created by investorideas is protected by copyright laws other than syndication rights. Our site does not make recommendations for purchases or sale of stocks, services or products. Nothing on our sites should be construed as an offer or solicitation to buy or sell products or securities. All investment involves risk and possible loss of investment. This site is currently compensated for news publication and distribution, social media and marketing, content creation and more. Contact each company directly regarding content and press release questions. Disclosure is posted for each compensated news release, content published /created if required but otherwise the news was not compensated for and was published for the sole interest of our readers and followers. More disclaimer info: http://www.investorideas.com/About/Disclaimer.asp Learn more about publishing your news release on the Investorideas.com newswire http://www.investorideas.com/News-Upload/

Additional info regarding BC Residents and global Investors: Effective September 15 2008 - all BC investors should review all OTC and Pink sheet listed companies for adherence in new disclosure filings and filing appropriate documents with Sedar. Read for more info: http://www.bcsc.bc.ca/release.aspx?id=6894. Global investors must adhere to regulations of each country.

Please read Investorideas.com privacy policy: http://www.investorideas.com/About/Private_Policy.asp