Investorideas.com  big ideas for global investors Search www.investorideas.com
   Member Access       Sign-up       Listings        Stock Directories       Research       Cleantech       Headlines        Video       New Ventures   




Live Longer, Get Richer with Patrick Cox

Source: Peter Byrne of The Life Sciences Report

Ideas get bigger when you share them...

May 8, 2014 (www.investorideas.com newswire) It's what every biotech investor dreams of: Transformational advances in healthcare technologies that allow us to live for centuries and accumulate wealth exponentially. Patrick Cox, editor of the Transformational Technology Alert, is doing his part to make the dream reality. In this interview, Cox tells The Life Sciences Report about two companies with proprietary intellectual property in DNA-based therapeutics and regenerative medicine that could change the world.

Join Investor Ideas Members to access the Renewable Energy stocks directory, water stocks, biotech stocks, defense stocks directories and the Insiders Corner

The Life Sciences Report: Patrick, you will be speaking at the Altegris Advisors LLC/Mauldin Economics conference in San Diego later in May on the topic of investing in a transformational world. What do you mean by "transformational"?

Patrick Cox: Transformational technologies change existing paradigms by causing massive disruption—destroying old industries while creating new ones. That is what we are now experiencing: The old ways are obsolescing as new solutions emerge.

TLSR: How is this playing out in the life sciences realm?

PC: Innovations and discoveries in the life sciences are bigger than in other fields. Especially with DNA, which is an ancient system of incredible complexity and sophistication. DNA-based breakthroughs in medical research are personally valuable to most people. The new DNA-based industry aims at curing diseases and extending the healthy portion of our lives significantly.

TLSR: What transformational companies do you like in the biotech world?

PC: I am not going to give away the companies I will be talking about at the San Diego conference.

TLSR: Even irrational beliefs can have market consequences.

PC: Correct, but how do you predict what irrationality will do? In the long run, productivity and profits will triumph.

TLSR: Are DNA-based vaccines predicted to be cheaper than the status quo?

PC: The status quo does not approach the same clinical targets. However, DNA vaccines are not terribly expensive. The plasmids on a large scale are inexpensive, and electroporation is not a costly technology. There is one machine and a disposable unit, so the production cost is not significant. These are pharmaceutical products, so the production cost does not really matter, as the prices are market-based.

TLSR: When a company makes a transformational breakthrough, such as in DNA vaccines, does this strengthen our economy?

PC: The macroeconomic drivers in life sciences are tied to the radical increase in life span that has taken place very recently. Since the American Revolution, life spans have more than doubled. In my lifetime, the average life span has increased by more than 30 years. We still have a social service model instituted when birth rates were high and life spans were relatively short. In 1950, just before I was born, I think there were about 16 workers for every retired person. Today, it's fewer than three working persons per retired person. Moreover, healthcare costs go up as we get older. Alzheimer's disease and heart disease are incredibly expensive to treat and live with. When people lived to 65 on average, those diseases were not particularly evident.

TLSR: What about regenerative medicine?

PC: Regenerative medicine is the most transformational of all the medical therapies, because it has the potential to reverse cellular aging. BioTime is working with stem cells that it can program to become cardiomyocytes, heart muscle cells. BioTime's researchers have seen the cells self-assemble in a dish and begin to beat like a heart! And we know from animal experiments that rejuvenated cardiomyocytes can integrate into the heart and heal damaged heart muscles. Stem cells are looking good.

TLSR: Does BioTime have a product based on this stem cell research?

PC: It has a subsidiary, ReCyte Therapeutics Inc., which is developing a delivery system for rejuvenated cardiomyocytes—sort of an epoxy that can be molded. It can make joints or flesh in reconstructive surgery. It creates a permanent matrix in which stem cells prosper, including in the heart. Third-party testing has validated this approach. But ReCyte Therapeutics' first product is slated to be endothelial precursors.

TSLR: What are endothelial precursors?

PC: Among gerontologists, there is a saying, "You're as old as your endothelium." The endothelium is a thin layer of cells inside the entire circulatory system—heart, arteries, capillaries. When you are young, it provides nitric oxide, which is an important neurotransmitter because it passes through cell walls. It is very short-lived, but it is responsible for vessel dilation. If you need additional blood flow for exercise or injury repair, or for any reason, the endothelium activates nitric oxide, which causes dilation and increases blood flow. When that does not work, there are all kinds of consequences—erectile dysfunction, hypertension, macular degeneration. It is a big killer, which is why the endothelium is the most important target for regenerative medicine.

TLSR: How can this process be industrialized?

PC: The endothelium does not regenerate by cell replication inside the cell walls. It exists as precursor cells inside the marrow of the larger bones, where the immune system resides. These cells simply circulate, find where they are needed, and engraft. If you were injected with your own endothelial precursor cells, they would migrate to the marrow of your large bones. We now know, from doing research on blood cancers, that the immune system can be rebooted without ablating bone marrow to generate replacement of old, sick endothelial precursors with new ones.

Michael West, who founded Geron Corp. (GERN:NASDAQ) and now owns Geron's IP, did this with cows. And Geron and BioTime have merged on the stem cell/regenerative medicine front. Dr. West ablated the bone marrow of one group of cows and then injected epithelial precursors. But as a control, he also injected the precursors into cows without ablative bone marrow. In both groups, the younger, healthier endothelial precursors replaced the older, unhealthier ones.

Blood cancer researchers have found the same thing. This is really a remarkably simple process. It is now possible to take cells from the patient, convert them to induced pluripotent stem cells [able to become any kind of cell], engineer them to become endothelial precursors, and then simply inject them into the patient. The precursors migrate to the bone marrow and replace the older, nonfunctioning or less functional endothelium with what is essentially a child's endothelium in terms of health and functionality.

TLSR: That sounds transformational in more ways than one.

PC: I'll say.

TLSR: How will the costs of healthcare decrease in your transformational model?

PC: Think about the cost of a heart attack and the subsequent care—hundreds of thousands of dollars over a lifetime right now. I predict that the cost of endothelial precursor therapy will eventually get that cost down to $10,000. Given the hundreds of thousands of dollars we spend on an Alzheimer's patient today, it's very unlikely that any of the drugs or the cells that are used to cure Alzheimer's will cost even a significant fraction of today's price tag.

TLSR: There will be less need for palliative care and radical surgery?

PC: That is right. Also, working careers will lengthen appreciably. People in the investment business know the impact of exponential growth on a portfolio. Despite the fact that everybody is worked up about income inequality, the real cause of income inequality is the fact that we have a much older and larger population. Older folks have worked long and grown their portfolios. As we extend life spans and careers, income inequality will increase spectacularly, as older people continue to get richer.

TLSR: What kind of life span do you look at for the average human of the future?

PC: A life span of centuries. Right now, our lives are bounded by our Hayflick limit—we are born with potential for about 120 cell replications. This is determined by the telomere, which is the nub on the zipper of an individual's DNA. Every time a cell replicates, we use up one of the telomere nubs. When we run out, the cell simply stops reproducing. Modern medicine is mostly trying to stop diseases that kill us before we reach our Hayflick limit. And we will do that. We will cure heart disease, cancer, Alzheimer's, liver disease; we will beat viruses; and we will end the factors that cause accelerated aging—inflammation, fibrosis, mitochondrial dysfunction. This will take us to a life span of about 120 years.

Beyond that, we will turn to regenerative medicine to rejuvenate cells, and there are a number of ways to do this. The first major breakthrough will probably be endothelial precursors rejuvenating endothelium, which will largely eliminate heart disease and stroke.

TLSR: Are we going to end up with 20 billion people who are 300 years old?

PC: That is a myth. If you look at the math, we are in serious depopulation right now. The West is disappearing. Iceland's birth rate is so low that the country has come to grips with the fact that it is disappearing as a culture. Japan is trying to increase its birth rates. Africa and the Middle East still have relatively high birth rates, but they are falling too. As they fall, we will see a diminishing global population. We are using a fraction of the earth's surface to produce food, minerals and energy. I am not at all worried about population.

TLSR: If you were able to live another 200 years, what would you do?

PC: I am interested in particle physics, and music and skateboarding.

TLSR: Thanks for your time today, Patrick.

PC: A pleasure.

Patrick Cox is the editor of Transformational Technology Alert. He has lived in the world of technology breakthroughs for the past 30 years. He has written more than 200 editorials for USA Today and has appeared in The Wall Street Journal and on CNN's "Crossfire" television program. In the late 1980s, he edited and published one of the first industry-insider software magazines, writing about topics like open-source and user-supported software long before those ideas were widely understood. Later, Cox wrote presentations and speeches for the CEO of Netscape. His consulting work has taken him to Fortune 500 boardrooms and inside the war rooms of national political candidates. His independent research is based solely on his investigations in transformational wealth-building companies and close consultation with Nobel Prize-winning economists and scientists.

Want to read more Life Sciences Report interviews like this? Sign up for our free e-newsletter, and you'll learn when new articles have been published. To see recent interviews with industry analysts and commentators, visit our Streetwise Interviews page.

DISCLOSURE:

1) Peter Byrne conducted this interview for Streetwise Reports LLC, publisher of The Gold Report, The Energy Report, The Life Sciences Report and The Mining Report, and provides services to Streetwise Reports as an independent contractor. He owns, or his family owns, shares of the following companies mentioned in this interview: None.
2) The following companies mentioned in the interview are sponsors of Streetwise Reports: None. Streetwise Reports does not accept stock in exchange for its services.
3) Patrick Cox: I own, or my family owns, shares of the following companies mentioned in this interview: None. I personally am, or my family is, paid by the following companies mentioned in this interview: None. My company has a financial relationship with the following companies mentioned in this interview: None. I was not paid by Streetwise Reports for participating in this interview. Comments and opinions expressed are my own comments and opinions. I had the opportunity to review the interview for accuracy as of the date of the interview and am responsible for the content of the interview.
4) Interviews are edited for clarity. Streetwise Reports does not make editorial comments or change experts' statements without their consent.
5) The interview does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer.
6) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their families are prohibited from making purchases and/or sales of those securities in the open market or otherwise during the up-to-four-week interval from the time of the interview until after it publishes.

Streetwise – The Life Sciences Report is Copyright © 2014 by Streetwise Reports LLC. All rights are reserved. Streetwise Reports LLC hereby grants an unrestricted license to use or disseminate this copyrighted material (i) only in whole (and always including this disclaimer), but (ii) never in part..

Streetwise Reports LLC does not guarantee the accuracy or thoroughness of the information reported.

Streetwise Reports LLC receives a fee from companies that are listed on the home page in the In This Issue section. Their sponsor pages may be considered advertising for the purposes of 18 U.S.C. 1734.

Participating companies provide the logos used in The Life Sciences Report. These logos are trademarks and are the property of the individual companies.

101 Second St., Suite 110
Petaluma, CA 94952
Tel.: (707) 981-8204
Fax: (707) 981-8998
Email: jluther@streetwisereports.com

More Info:

This news is published on the Investorideas.com Newswire and its syndicated partner network

Publish Your News - Send a release
News now!

Get free news alerts: Sign up here

Published at the Investorideas.com Newswire - Big ideas for Global Investors

Disclaimer/ Disclosure:The Investorideas.com newswire is a third party publisher of news and research as well as creates original content as a news source. Original content created by investorideas is protected by copyright laws other than syndication rights. Investorideas is a news source on Google news and Linkedintoday plus hundreds of syndication partners. Our site does not make recommendations for purchases or sale of stocks or products. Nothing on our sites should be construed as an offer or solicitation to buy or sell products or securities. All investment involves risk and possible loss of investment. This site is currently compensated by featured companies, news submissions, content marketing and online advertising. Contact each company directly for press release questions. Disclosure is posted on each release if required but otherwise the news was not compensated for and is published for the sole interest of our readers. More disclaimer info: http://www.investorideas.com/About/Disclaimer.asp

BC Residents and Investor Disclaimer : Effective September 15 2008 - all BC investors should review all OTC and Pink sheet listed companies for adherence in new disclosure filings and filing appropriate documents with Sedar. Read for more info: http://www.bcsc.bc.ca/release.aspx?id=6894. Global investors must adhere to regulations of each country.



Free News Alerts
Email:  

Read more News





TOP

Investor Ideas © 2000 - 2014 InvestorIdeas.com®, ECON

Free Investor Stock Alerts
Sign up here

login | logout | about us | contact | disclaimer / disclosure |
advertise | company profile directory | partners / links |
job search | privacy policy | trade | services | sitemap |